Project lead: Detecting systemic vasoconstriction via a chest patch

Vasoconstriction is a crucial physiological process that serves as the body’s primary blood pressure regulation mechanism and a key marker of numerous harmful health conditions. The ability to detect vasoconstriction in real time would be crucial for detecting blood pressure, identifying sympathetic arousals, characterizing patient wellbeing, detecting sickle cell anemia attacks early, and identifying complications caused by hypertension medications.

However, vasoconstriction manifests weakly in traditional photoplethysmogram (PPG) measurement locations, like the finger, toe, and ear. Here, I developed a wireless chest patch to capture PPG signals from the sternum, an anatomical region that exhibits a robust vasoconstrictive response.

In overnight trials with patients with sleep apnea, the device shows a high agreement (r-squared = 0.74) in vasoconstriction detection with a commercial system, demonstrating its potential use in portable, continuous, long-term vasoconstriction monitoring.

Relevant Papers

Soft wireless sternal patch to detect systemic vasoconstriction using photoplethysmography

iScience (2023)

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